SULFASALAZINE

• Action to be taken: No action needed
  
• Rationale: Sulfasalazine is metabolized by intestinal bacteria to SP and 5­ASA. The primary route of metabolism of SP is via acetylation to form AcSP. Based on available data sulfasalazine is not expected to interact with cannabis.
  

MESALAMINE

• Action to be taken: No action needed
• Rationale:The major metabolite of mesalamine (5-aminosalicylic acid) is N-acetyl-5­ aminosalicylic acid. Its formation is brought about by N-acetyltransferase activity in the liver and intestinal mucosa. No investigations have been performed between LIALDA and other drugs. However based on its metabolic profile mesalamine is not expected to interact with cannabis.
  

References

1. Azulfinide (sulfasalazine) package insert. Pfizer Inc. NY, NY 2012
   
2. Lialda (meslalamine) package insert. 2009