Action to be taken: No action needed
Rationale:Lithium has a low therapeutic index and is renally excreted and hence has renally-mediated but not hepatically-mediated drug-drug interactions. Since cannabis is extensively metabolized by CYP enzymes its not expected for cannabis to interact with lithium
Rationale:Lithium has a low therapeutic index and is renally excreted and hence has renally-mediated but not hepatically-mediated drug-drug interactions. Since cannabis is extensively metabolized by CYP enzymes its not expected for cannabis to interact with lithium
References
- Ketter TA, Frye MA, Corá-Locatelli G, Kimbrell TA, Post RM. Metabolism and Excretion of Mood Stabilizers and New Anticonvulsants. Cellular and Molecular Neurobiology. 1999;19:511-532.
- Watanabe K, Yamaori S, Funahashi T, et al. Cytochrome P450 enzymes involved in the metabolism of tetrahydrocannabinols and cannabinol by human hepatic microsomes. Life Sci. 2007;80:1415-1419.