GPI MEDICAL MARIJUANA CLINIC & RESOURCES
  • Home
  • Company
    • About Us
    • Services
  • Support
    • For Patients >
      • Qualifying Conditions
      • Cost of Visit
      • How Marijuana Works
      • Side Effects and Safety
      • Approved Formulations and Dosing
      • Dispensaries
      • Caregivers
      • How to Register ?
      • FAQ
    • For Clinicians >
      • Research
      • Drug Interactions
  • Contact

Local Anesthetics

LIDOCAINE
  • Cytochrome P450 enzyme substrate: CYP1A2 and CYP3A4
  • Action to be taken: No action needed
  • Rationale: Although lidocaine is a sensitive CYP3A and CYP1A2 substrate, topical preparations are not expected to increase lidocaine-related adverse reactions.
References
  1. Wang JS, Backman JT, Taavitsainen P, et al. Involvement of CYP1A2 and CYP3A4 in lidocaine N-deethylation and 3-hydroxylation in humans. Drug Metab Dispos 2000;28:959-65.
  2. Orlando R, Piccoli P, De Martin S, et al. Cytochrome P450 1A2 is a major determinant of lidocaine metabolism in vivo: effects of liver function. Clin Pharmacol Ther 2004;75:80-8.

Company

About Us
Services

Support

Patients 
Clinicians

Contact

Contact Us
Last Updated: May 2018.
  • Home
  • Company
    • About Us
    • Services
  • Support
    • For Patients >
      • Qualifying Conditions
      • Cost of Visit
      • How Marijuana Works
      • Side Effects and Safety
      • Approved Formulations and Dosing
      • Dispensaries
      • Caregivers
      • How to Register ?
      • FAQ
    • For Clinicians >
      • Research
      • Drug Interactions
  • Contact